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Clinical Question: Is sildenafil (Viagra) more effective than bosentan (Tracleer) in the treatment of patients with class III pulmonary hypertension?
Setting: Outpatient (specialty)
Study Design: Randomized controlled trial (double-blinded)
Allocation: Concealed
Synopsis: Investigators recruited consecutive patients with World Health Organization class III pulmonary hypertension. These patients could walk only 150 to 450 meters in six minutes. Patients with threefold elevations of liver enzymes, previous treatment with sildenafil or bosentan, and those in need of urgent therapy were excluded. Eligible patients were randomized (allocated via central computer) to receive sildenafil (n = 14) or bosentan (n = 12).
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